Crosslinking of gelatin by ring opening metathesis under aqueous conditions - An exploratory study
نویسندگان
چکیده
Ring-opening metathesis catalysis has received little attention as a means to functionalize or crosslink biopolymers in water since the required catalysts are not usually stable under these conditions. However, biopolymer solubility suggests such a procedure. We show that Grubbs 1 and 2 generation catalysts (in emulsion) as well as a water-soluble Hoveyda-Grubbs catalyst can be applied to crosslink glycidyl methacrylated gelatin with norbornene dicarboxylic acid in water by a cross metathesis-ring opening metathesis approach. A mechanistic study suggests cross metathesis between the functionalized polymer and the cyclic olefin acts as an initiating step for the crosslinking reaction.
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